High dose methylprednisolone in severe acute transverse myelopathy
(1997) Archives of Disease in Childhood — Vol. 76, n° 2, p. 167-168 (1997)
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- Abstract
- No effective treatment has been shown for patients with acute transverse myelopathy. In an open study five children with severe acute transverse myelopathy were treated with intravenous methylprednisolone and compared with a historical group of 10 patients. The results show that in the methylprednisolone treatment group compared with the historical group of 10 patients: the median time to walk independently was significantly reduced (23 v 97 days); the proportion of patients with a full recovery within 12 months was significantly higher (80 v 10%); all patients had complete motor recovery within one year in contrast with only two of 10 patients in the historical group; and serious adverse effects did not occur. This pilot study suggests that high dose methylprednisolone is effective in the treatment of acute transverse myelopathy.
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Citations
Sébire, G., Hollenberg, H., Meyer, L., Huault, G., Landrieu, P., & Tardieu, M. (1997). High dose methylprednisolone in severe acute transverse myelopathy. Archives of Disease in Childhood, 76(2), 167-168. https://doi.org/10.1136/adc.76.2.167 (Original work published 1997)