Recurrent seizure and sustained encephalopathy associated with dimethylsulfoxide-preserved stem cell infusion.
(2005) Leukemia and Lymphoma — Vol. 46, n° 11, p. 1671-1674 (2005)
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- We report the case of a patient who received two infusions of dimethylsulfoxide (DMSO) cryopreserved autologous peripheral blood progenitor cells (PBPCs) after myeloablative chemotherapy for a relapsing lymphoma. A 49-year-old man presented an episode of tonic-clonic seizure over a few minutes after the start of each infusion and developed a profound and sustained but reversible encephalopathy with coma after the second infusion. The patient's neurological condition correlated well with the electrophysiological findings (electroencephalogram and multimodality evoked potentials) and, to a lesser extent, with the radiological abnormalities (magnetic resonance imaging). Severe but reversible neurological complications may occur with the infusion of PBPCs cryopreserved with DMSO.
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Citations
Bauwens, D., Hantson, P., Laterre, P.-F., Michaux, L., Latinne, D., de Tourtchaninoff, M., Cosnard, G., & Hernalsteen, D. (2005). Recurrent seizure and sustained encephalopathy associated with dimethylsulfoxide-preserved stem cell infusion. Leukemia and Lymphoma, 46(11), 1671-1674. https://doi.org/10.1080/10428190500235611 (Original work published 2005)