Major depressive disorder is a huge public health problem. Despite the existence of a range of effective antidepressants, many patients fail to achieve complete remission of their symptoms, or if they do, they go on to suffer relapse or recurrence. Broad remission is more likely to be achieved using double action antidepressants that address a wider range of symptoms. It is also important to continue therapy beyond the acute stage into maintenance therapy, if complete remission is to be achieved and maintained in the long term.
Constant, E. L. (2007). Intérêt de la duloxétine (Cymbalta®) en pratique clinique quotidienne. Louvain médical, 126(1), 35-38. https://hdl.handle.net/2078.5/95726 (Original work published 2007)