Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study
(2018) European Respiratory Journal — Vol. 51, n° 5, p. 1702523 (2018)
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- Omalizumab is a treatment option for severe allergic asthma irrespective of blood eosinophil count ABSTRACT Omalizumab is a monoclonal anti-IgE antibody used to treat severe allergic asthma (SAA). The aim of the STELLAIR study was to determine the importance of pre-treatment blood eosinophil count as a predictive measure for response to omalizumab. This retrospective real-life study was conducted in France between December 2015 and September 2016 using medical records of SAA omalizumab-treated patients. Response to omalizumab was assessed by three criteria: physician evaluation, reduction of ⩾40% in annual exacerbation rate and a combination of both. Response rate was calculated according to blood eosinophil count measured in the year prior to omalizumab initiation. 872 SAA omalizumab-treated patients were included by 78 physicians (723 adults (age ⩾18 years) and 149 minors (age 6-17 years)). Blood eosinophil count was ⩾300 cells·µL −1 in 52.1% of adults and 73.8% of minors. By physician evaluation, 67.2% of adults and 77.2% of minors were responders and 71.1% adults and 78.5% minors had a ⩾40% reduction in the exacerbation rate. In adults, the response rate for combined criteria was 58.4% (95% CI 53.2-63.4%) for blood eosinophils ⩾300 cells·µL −1 (n=377) and 58.1% (95% CI 52.7-63.4%) for blood eosinophils <300 cells·µL −1 (n=346). This study shows that a large proportion of patients with SAA have a blood eosinophil count ⩾300 cells·µL −1 , and suggests that omalizumab effectiveness is similar in "high" and "low" eosinophil subgroups.
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Humbert, M., Taillé, C., Mala, L., Le Gros, V., Just, J., Molimard, M., & Tiotiu-Cepuc, I. (2018). Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study. European Respiratory Journal, 51(5), 1702523. https://doi.org/10.1183/13993003.02523-2017 (Original work published 2018)