Prognostic value of prostate circulating cells detection in prostate cancer patients: a prospective study.
(2009) The British journal of cancer — Vol. 100, n° 4, p. 608-610 (2009)
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- Abstract
- In clinically organ-confined prostate cancer patients, bloodstream tumour cell dissemination generally occurs, and may be enhanced by surgical prostate manipulation. To evaluate cancer-cell seeding impact upon patient recurrence-free survival, 155 patients were prospectively enrolled then followed. Here, 57 patients presented blood prostate cell shedding preoperatively and intraoperatively (group I). Of the 98 preoperatively negative patients, 53 (54%) remained negative (group II) and 45 (46%) became intraoperatively positive (group III). Median biological and clinical recurrence-free time was far shorter in group I (36.2 months, P<0.0001) than in group II (69.6 months) but did not significantly differ in group II and III (69.6 months vs 65.0). Such 5-year follow-up data show that preoperative circulating prostate cells are an independent prognosis factor of recurrence. Moreover, tumour handling induces cancer-cell seeding but surgical blood dissemination does not accelerate cancer evolution.
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Eschwège, P., Moutereau, S., Droupy, S., Douard, R., Gala, J.-L., Benoit, G., Conti, M., Manivet, P., & Loric, S. (2009). Prognostic value of prostate circulating cells detection in prostate cancer patients: a prospective study. The British journal of cancer, 100(4), 608-610. https://doi.org/10.1038/sj.bjc.6604912 (Original work published 2009)