Hypoxia increases the association of 4E-binding protein 1 with the initiation factor 4E in isolated rat hepatocytes.
(1999) FEBS Letters — Vol. 446, n° 1, p. 55-59 (1999)
Files
pdfdocument.pdf
Restricted Access - Adobe PDF
- 399.92 KB
Details
- Authors
- Abstract
- Incubation of hepatocytes under hypoxia increases binding of translation initiation factor eIF-4E to its inhibitory regulator 4E-BP1, and this correlates with dephosphorylation of 4E-BP1. Rapamycin induced the same effect in aerobic cells but no additive effect was observed when hypoxic cells were treated with rapamycin. This enhanced association of 4E-BP1 with eIF-4E might be mediated by mTOR. Nevertheless, only hypoxia produces a rapid inhibition of protein synthesis. Although hypoxia might be signalling via the rapamycin-sensitive pathway by changing eIF-4E availability, such a pathway is unlikely to be responsible for the depression in overall protein synthesis under hypoxia.
- Affiliations
Citations
Tinton, S. A., & Buc Calderon, P. (1999). Hypoxia increases the association of 4E-binding protein 1 with the initiation factor 4E in isolated rat hepatocytes. FEBS Letters, 446(1), 55-59. https://doi.org/10.1016/S0014-5793(99)00185-4 (Original work published 1999)