Good response to pulsed dye laser in patients with capillary malformation-arteriovenous malformation syndrome (CM-AVM)

Iznardo Helena;Roé Esther;Puig Louis;Vikkula, Miikka;Baselga Eulalia;et.al.
(2020) Pediatric Dermatology — (2020)

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Authors
  • Iznardo HelenaDepartment of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Author
  • Roé EstherDepartment of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Author
  • Puig LouisDepartment of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Author
  • Vikkula, Miikkaorcid-logoUCLouvain
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  • Baselga EulaliaDepartment of Dermatology, Hospital Sant Joan de Déu, Barcelona, Spain
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Abstract
Capillary malformation-arteriovenous malformation syndrome (CM-AVM) is an au- tosomal dominant disorder caused by heterozygous mutations in RASA1 and EPHB4. Capillary stains in CM-AVM are compatible with Schöbinger's phase I AVMs. Vascular laser has been classically contraindicated for the treatment of AVMs, as there is a fear of accelerating their progression. In this study, we have treated capillary stains in five CM-AVM patients with pulsed dye laser, with improvement and without worsening or recurrence of the lesions after 1 year of clinical and ultrasound follow-up.
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Iznardo Helena, Roé Esther, Puig Louis, Vikkula, M., Lopez-Sanchez Cristina, & Baselga Eulalia. (2020). Good response to pulsed dye laser in patients with capillary malformation-arteriovenous malformation syndrome (CM-AVM). Pediatric Dermatology. Accepted/in-press. https://doi.org/10.1111/pde.14095 (Original work published 2020)