Probing solvent effects on mixed aggregates associating a chiral lithium amide and n-BuLi by NMR: from structure to reactivity

Barozzino Consiglio, Gabriella;Rouen, Mathieu;Oulyadi, Hassan;Harrison-Marchand, Anne;Maddaluno, Jacques
(2014) Dalton Trans. — Vol. 43, n° 38, p. 14219-14228 (2014)

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Abstract
An NMR study of a 1 : 1 mixture of a chiral lithium amide (4a) and n-BuLi shows that depending on the solvent employed (Et2O or THF) a mixed aggregate can form in proportions that are directly related to the ees measured during the enantioselective alkylation of o-tolualdehyde by these same species.
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Barozzino Consiglio, G., Rouen, M., Oulyadi, H., Harrison-Marchand, A., & Maddaluno, J. (2014). Probing solvent effects on mixed aggregates associating a chiral lithium amide and n-BuLi by NMR: from structure to reactivity. Dalton Trans., 43(38), 14219-14228. https://doi.org/10.1039/c4dt01156b (Original work published 2014)