Comparison of chemotherapy to radiotherapy as consolidation of complete or good partial response after six cycles of chemotherapy for patients with advanced Hodgkin's disease: results of the Groupe d'etudes des Lymphomes de l'Adulte H89 trial

Ferme, C;Ferrant, Augustin;Sebban, C.;Hennequin, C;Lepage, E.;et.al.
(2000) Blood — Vol. 95, n° 7, p. 2246-2252 (2000)

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  • Ferme, C
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  • Ferrant, AugustinUCLouvain
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  • Sebban, C.
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  • Hennequin, C
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  • Lepage, E.
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Abstract
The treatment of advanced Hodgkin's disease (HD) with chemotherapy (CTx) alone or combined modality treatments has been controversial. In 1989, we designed a randomized study to compare 2 cycles of CTx to (sub)total nodal irradiation (RTx) as consolidation treatments for patients with stage IIIB/IV Ho in complete remission (CR) or good partial response after 6 cycles of CTx, A total of 559 patients were randomized to receive 6 cycles of MOPP/ABV (mechlorethamine, vincristine, procarbazine, prednisone/ Adriamycin [doxorubicin], bleomycin, vinblastine) hybrid (n = 266) or ABVPP (n = 267), After induction treatment, 418 patients could be evaluated for the consolidation phase. With a median follow-up of 48 months, the B-year disease-free survival estimates were 80% for 8 cycles of MOPP/ABV, 82% for 6 cycles of MOPP/ABV plus RTx, 68% for 8 cycles of ABVPP, and 75% for 6 cycles of ABVPP plus RTx (P =.01). The 5-year disease-free survival estimates did not differ between CTx and RTx, 74% and 79%, respectively (P =.07), After MOPP/ABV, the B-year overall survival estimates did not differ between CTx and RTx, 85% and 88%, respectively (P =.2). After ABVPP, the 5-year survival estimates were 94% for CTx and 78% for RTx (P =.002), These results showed that RTx was not superior to CTx consolidation after doxorubicin-induced CR for patients with advanced No, Because of the uncertainty of obtaining a prolonged second remission for patients relapsing after CTx and RTx and the possible long-term effects of RTx, we prefer 8 cycles of CTx as standard treatment when a CR has been achieved atter 6 cycles. (Blood, 2000;95:2246-2252) (C) 2000 by The American Society of Hematology.
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Ferme, C., Ferrant, A., Sebban, C., Hennequin, C., Divine, M., Lederlin, P., Gabarre, J., Caillot, D., Bordessoule, D., Brice, P., Moullet, I., Berger, F., & Lepage, E. (2000). Comparison of chemotherapy to radiotherapy as consolidation of complete or good partial response after six cycles of chemotherapy for patients with advanced Hodgkin’s disease: results of the Groupe d’etudes des Lymphomes de l’Adulte H89 trial. Blood, 95(7), 2246-2252. https://hdl.handle.net/2078.5/139899 (Original work published 2000)