Effects of long-term xamoterol therapy on the left ventricular mechanical efficiency in patients with ischemic heart disease.
(1989) Basic Research in Cardiology — Vol. 84 Suppl 1, p. 157-162 (1989)
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- Abstract
- Myocardial oxygen uptake and an index of mechanical left ventricular efficiency were determined in basal conditions or during prolonged therapy with the new beta 1-adrenoceptor partial agonist xamoterol in 16 patients with mild to moderate ischemic heart failure. During xamoterol therapy, left ventricular end-diastolic pressure decreased from 24.4 +/- 6.5 to 17.8 +/- 8.6 mm Hg (P less than 0.01) and the isovolumic index of inotropic state (dP/dt)/DP40 increased by 14% (P less than 0.01). The heart rate increased slightly and the mean systolic and peak systolic wall stress also tended to increase (+ 7%; NS) but myocardial oxygen uptake (14.1 vs 14.7 ml/min; NS) and the index of efficiency (8.77 +/- 3.44 to 8.82 +/- 4.27; NS) were not significantly modified. In conclusion, prolonged therapy with xamoterol was not accompanied by a deterioration in the mechanical efficiency of the ventricle, even in patients with ischemic heart disease.
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Pouleur, H., van Eyll, C., Etienne, J., Van Mechelen, H., Vuylsteke, A., & Rousseau, M. (1989). Effects of long-term xamoterol therapy on the left ventricular mechanical efficiency in patients with ischemic heart disease. Basic Research in Cardiology, 84 Suppl 1, 157-162. https://doi.org/10.1007/BF02650355 (Original work published 1989)