Individuals exhibit considerable and unpredictable variability in painful percepts in response to the same nociceptive stimulus. Previous work has found neural responses that, while not necessarily responsible for the painful percepts themselves, can still correlate well with intensity of pain perception within a given individual. However, there is no reliable neural response reflecting the variability in pain perception across individuals. We observed a clear dissociation between the large number of neural measures that reflected subjective pain ratings at within-subject level but not across individuals, and γ-ERS, which reliably distinguished subjective ratings within the same individual but also coded pain sensitivity across different individuals.
university college londonNeuroscience, Physiology and Pharmacology
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Lenoir, C. (2019). Neural markers of pain and its chronification. Wellcome Trust Pain Research Update day, London, UK. https://hdl.handle.net/2078.5/91035