Age trend in hepatitis C virus genotype distribution as seen in a Brussels teaching hospital.
(2001) Acta Clinica Belgica (Multilingual Edition) — Vol. 56, n° 4, p. 220-224 (2001)
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- Abstract
- The hepatitis C virus genotype distribution was studied among age groups in 501 referred patients with chronic hepatitis C by INNO-LiPA HCV II (Innogenetics, Belgium). Ten patients had coinfection with several genotypes. Two hundred seventy of 491 singly infected individuals (57%) had 1b, 66 (13.4%) 3a, 57 (11.6%) 1a. HCV subtype 1b was predominant but its prevalence increased with age (76.5% of patients born in the '20s, 39.3% in the '70s) (P < 0.0001). Three possibilities could explain the shift towards a wider variety of genotypes in younger age. (1) 1b could be the original subtypes in this population, (2) the non-1b subtypes could give less chronic carriers, (3) the non-1b subtypes could have a higher mortality, which seems improbable. The 1b genotype seems the oldest subtype in our country while others were imported later through increased population movements and changing habits.
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Citations
de Moreau de Gerbehaye, A. I., Bodéus, M., & Goubau, P. (2001). Age trend in hepatitis C virus genotype distribution as seen in a Brussels teaching hospital. Acta Clinica Belgica (Multilingual Edition), 56(4), 220-224. https://hdl.handle.net/2078.5/97616 (Original work published 2001)