Chronic myeloid leukemia with a rare variant Philadelphia translocation: t(9;22;21)(q34;q11;q22).
(2000) Cancer Genetics and Cytogenetics — Vol. 116, n° 2, p. 166-169 (2000)
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- Abstract
- A case of chronic myeloid leukemia displaying an uncommon t(21;22)(q22;q11) is reported. For the first time, this translocation has been characterized by fluorescence in situ hybridization (FISH) and the reverse transcriptase polymerase chain reaction (RT-PCR). FISH, with the use of whole-chromosome painting probes and probes specific for the BCR and ABL genes, showed a three-way variant Philadelphia translocation (9;22;21)(q34;q11;q22) with a BCR/ABL fusion residing on the der(22). In addition, RT-PCR demonstrated a b2a3 BCR/ABL fusion transcript. Underlying mechanisms and prognostic implications are discussed.
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Citations
Guillaume, B., Ameye, G., Libouton, J.-M., Dierlamm, J., Vaerman, J. L., Dumoulin, C., Straetmans, N., Ferrant, A., & Michaux, L. (2000). Chronic myeloid leukemia with a rare variant Philadelphia translocation: t(9;22;21)(q34;q11;q22). Cancer Genetics and Cytogenetics, 116(2), 166-169. https://doi.org/10.1016/S0165-4608(99)00115-6 (Original work published 2000)