This study assessed the long-term effects of prolonged-release tacrolimus (Advagraf(®) [Tacrolimus QD]), which has been developed to provide similar efficacy and safety to twice-daily tacrolimus (Prograf(®) [Tacrolimus BID]) with the added benefit of once-daily dosing.
van Hooff, J. P., Alloway, R. R., Trunečka, P., & Mourad, M. (2011). Four-year experience with tacrolimus once-daily prolonged release in patients from phase II conversion and de novo kidney, liver, and heart studies. Clinical Transplantation, 25(1), E1-E12. https://doi.org/10.1111/j.1399-0012.2010.01377.x (Original work published 2011)