A double-blind comparison of 0.125% ropivacaine with sufentanil and 0.125% bupivacaine with sufentanil for epidural labor analgesia

Gautier, Ph. E.;De Kock, Marc;Van Steenberge, A;Fanard, L;Hody, JL
(1999) Anesthesiology —

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Authors
  • Gautier, Ph. E.Autre
    Author
  • De Kock, MarcUCLouvain
    Author
  • Van Steenberge, A
    Author
  • Fanard, L
    Author
  • Hody, JL
    Author
Abstract
Background This study intends to evaluate the benefits of the administration of intermittent bolus doses of ropivacaine (0.125%) compared with bupivacaine (0.125%) after addition of sufentanil for analgesia during labor. Methods: One hundred thirty American Society of Anesthesiologists physical status 1 or 2 parturients were studied. The 90 initial patients were assigned randomly to receive 10 mi bupivacaine, 0.125%, plus 7.5 mu g sufentanil (initial bupivacaine 0.125% group) or ropivacaine, 0.125%, plus 7.5 mu g sufentanil (ropivacaine 0.125% group). Forty additional patients were recruited and received 0.125% bupivacaine plus 7.5 mu g sufentanil (additional bupivacaine 0.125% group) or 0.100% bupivacaine plus 7.5 pg sufentanil (additional bupivacaine 0.100% group). The duration of analgesia, visual analogue scores for pain, motor blockade (using a six-point modified Bromage scale), patient satisfaction scores, nausea, pruritus, heart rate, and blood pressure were recorded. Results: Bupivacaine 0.125% and ropivacaine 0.125% coadministered with sufentanil provided rapid and complete analgesia. Onset of analgesia occurred after +/- 15 min and lasted +/- 90 min. After the third epidural injection, patients in the ropivacaine group experienced significantly less severe motor blockade than patients in the initial bupivacaine 0.125% group. At this point, 93% of the patients in the ropivacaine group were free from motor impairment versus 66% in the bupivacaine group (P < 0.05). Comparable levels of motor blockade were obtained in both additional groups. Patients' evaluation of their analgesia was worst in the bupivacaine 0.100% group. Conclusions: Ropivacaine 0.125% with sufentanil affords reliable analgesia with minimal motor blockade.
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Gautier, Ph. E., De Kock, M., Van Steenberge, A., Fanard, L., & Hody, J. (1999). A double-blind comparison of 0.125% ropivacaine with sufentanil and 0.125% bupivacaine with sufentanil for epidural labor analgesia. Anesthesiology. https://doi.org/10.1097/00000542-199903000-00020