Polysomy 13 with concomitant deletion of 13q13-14 involving the retinoblastoma gene and the D13S25 locus in a case of acute myeloid leukemia
(2000) Cancer Genetics and Cytogenetics — Vol. 119, n° 2, p. 158-161 (2000)
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- Abstract
- We herein describe a case of acute myeloblastic leukemia (AML), FAB subtype M4, with an unfavorable clinical course and a complex karyotype, including 4-9 copies of chromosome 13. Polysomy 13 was a result of clonal evolution. Fluorescence in situ hybridization (FISH) revealed a cytogenetically unrecognizable deletion within 13q13-14 that included the retinoblastoma gene (RB) and the D13S25 locus in all but one copy of chromosome 13. The only chromosome 13 that did not show a deletion affecting the q13-14 region was translocated to chromosome 7, resulting in a dic(7;13)(q21;p11). In this case, the coexistence of polysomy and a partial deletion within the same chromosome point toward a possible formation of a fusion product with oncogenic potential and its consecutive amplification as a critical alteration in this case. (C) 2000 Elsevier Science Inc. All rights reserved.
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Stefanova, M., Michaux, L., Dierlamm, J., Leberecht, P., Seeger, D., Hinz, K., & Hossfeld, D. (2000). Polysomy 13 with concomitant deletion of 13q13-14 involving the retinoblastoma gene and the D13S25 locus in a case of acute myeloid leukemia. Cancer Genetics and Cytogenetics, 119(2), 158-161. https://doi.org/10.1016/S0165-4608(99)00230-7 (Original work published 2000)