Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target
(2019) Frontiers in Oncology — Vol. 9 (2019) (2019)
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- Authors
- Abstract
- Over the years, substantial evidence has definitively confirmed the existence of cancer stem-like cells within tumors such as Glioblastoma (GBM). The importance of Glioblastoma stem-like cells (GSCs) in tumor progression and relapse clearly highlights that cancer eradication requires killing of GSCs that are intrinsically resistant to conventional therapies as well as eradication of the non-GSCs cells since GSCs emergence relies on a dynamic process. The past decade of research highlights that metabolism is a significant player in tumor progression and actually might orchestrate it. The growing interest in cancer metabolism reprogrammation can lead to innovative approaches exploiting metabolic vulnerabilities of cancer cells. These approaches are challenging since they require overcoming the compensatory and adaptive responses of GSCs. In this review, we will summarize the current knowledge on GSCs with a particular focus on their metabolic complexity. We will also discuss potential approaches targeting GSCs metabolism to potentially improve clinical care.
- Affiliations
Université de Nantes Centre de Recherche en Cancérologie et Immunologie Nantes-Angers UMR1232, INSERM
Citations
Garnier, D., Renoult, O., Alves-Guerra, M.-C., Paris, F., & Pecqueur, C. (2019). Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target. Frontiers in Oncology, 9 (2019). https://doi.org/10.3389/fonc.2019.00118 (Original work published 2019)