Ethoxycarbonyl functionalized Tröger's base alongside its congener dihydroquinazoline: A trick with crystallization

Kovalenko, Vitaly;TUMANOV, Nikolay;Vasiutovich, Kiryl;Leyssens, Tom
(2020) Chemical Data Collections — Vol. 25, p. 100339 (2020)

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Authors
  • Kovalenko, Vitaly
    Author
  • TUMANOV, Nikolayorcid-logoUNamur
    Author
  • Vasiutovich, Kiryl
    Author
  • Leyssens, TomUCLouvain
    Author
Abstract
The synthesis of ethoxycarbonyl functionalized Tröger's base is accompanied by the formation of a considerable amount of a 3,4-dihydroquinazoline by-product. We found that both compounds can be readily isolated from reaction mixture on a preparative scale by standard crystallization from appropriate solvents.
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Citations

Kovalenko, V., TUMANOV, N., Vasiutovich, K., & Leyssens, T. (2020). Ethoxycarbonyl functionalized Tröger’s base alongside its congener dihydroquinazoline: A trick with crystallization. Chemical Data Collections, 25, 100339. https://doi.org/10.1016/j.cdc.2020.100339 (Original work published 2020)