Structural characterization of sol-gel derived Sr-substituted calcium phosphates with anti-osteoporotic and anti-inflammatory properties
(2008) Journal of Materials Chemistry — Vol. 18, n° 30, p. 3593-3600 (2008)
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- Abstract
- Sol-gel chemistry has been successfully used to prepare un-doped and Sr-doped calcium phosphate ceramics exhibiting a porous structure. The samples composition is very close to the nominal one. All samples present phase mixtures of mainly hydroxyapatite (HAp) and tricalcium phosphate (β-TCP). Doping with Sr2+ ions has a clear effect on the proportions of the different phases, increasing the amount of β-TCP. An amorphous phase is also observed incorporating some 40% of the total amount of strontium. Strontium ions also substitute for calcium both in HAp and β-TCP in specific sites that have been determined from Rietveld refinement on synchrotron powder diffraction data. The soluble amorphous and TCP phases are responsible for a beneficial partial release of strontium ions in solution during interactions between the material and biological fluids. Preliminary in vitro study demonstrates anti-inflammatory effects of strontium for human monocytes cultured in contact with calcium phosphates. © 2008 The Royal Society of Chemistry.
- Affiliations
ESRF, Grenoble (France) Chimie
Citations
Renaudin, G., Laquerrière, P., Filinchuk, Y., Jallot, E., & Nedelec, J. M. (2008). Structural characterization of sol-gel derived Sr-substituted calcium phosphates with anti-osteoporotic and anti-inflammatory properties. Journal of Materials Chemistry, 18(30), 3593-3600. https://doi.org/10.1039/b804140g (Original work published 2008)