Comment on "Paraneoplastic encephalomyelitis revealing burned-out seminoma": confirmed case of anti-Kelch-like protein-11 encephalomyelitis.
(2022) Acta Neurologica Belgica — Vol. 122, n° 1, p. 257-258 (2022)
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- (en) Paraneoplastic neurological syndromes occur in association with cancer and have an immune-mediated pathogenesis, but sometimes neuronal antibodies cannot be identified. Recently, Guilmot et al. published a Letter to the Editor describing a case of paraneoplastic encephalomyelitis that led to the diagnosis of a burned-out seminoma, but the patient remained seronegative for all the onconeuronal antibodies known at that time. The 52-year-old patient presented with hearing loss, vertigo, diplopia, nystagmus, and ataxia, and later developed gait difficulties, limb incoordination, and left arm weakness. Repeated brain magnetic resonance imaging (MRI) revealed T2/FLAIR hyperintensities in both thalami, brainstem, and right temporal lobe, while spinal cord imaging showed an extensive myelitis. [...]
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Maldonado Slootjes, S., Landa, J., Sabater, L., & Van Pesch, V. (2022). Comment on “Paraneoplastic encephalomyelitis revealing burned-out seminoma”: confirmed case of anti-Kelch-like protein-11 encephalomyelitis. Acta Neurologica Belgica, 122(1), 257-258. https://doi.org/10.1007/s13760-021-01813-z (Original work published 2022)