Unprecedented copper(I) bifluoride complexes: Synthesis, characterization and reactivity

Vergote, Thomas;Nahra, Fady;Welle, Alexandre;Luhmer, Michel;Leyssens, Tom;et.al.
(2012) Chemistry: A European Journal — Vol. 18, n° 3, p. 793-798 (2012)

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Authors
  • Vergote, ThomasUCLouvain
    Author
  • Nahra, FadyUCLouvain
    Author
  • Welle, AlexandreUCLouvain
    Author
  • Luhmer, MichelUCLouvain
    Author
  • Mager, NathalieUCLouvain
    Author
  • Riant, OlivierUCLouvain
    Author
  • Leyssens, TomUCLouvain
    Author
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Abstract
To be or not to bifluoride: Two synthetic pathways to unprecedented N-heterocyclic carbene copper(I) bifluoride complexes have been developed (see scheme). Catalytic tests demonstrated that copper(I) bifluorides are very efficient catalysts, which do not require any additional activating agent. The first Cu-catalyzed diastereoselective allylation of (R)-N-tert-butanesulfinyl aldimines was also established. The method enables efficient, simple and general synthesis of enantiomerically enriched homoallylic amines at room temperature in high yields.
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Vergote, T., Nahra, F., Welle, A., Luhmer, M., Wouters, J., Mager, N., Riant, O., & Leyssens, T. (2012). Unprecedented copper(I) bifluoride complexes: Synthesis, characterization and reactivity. Chemistry: A European Journal, 18(3), 793-798. https://doi.org/10.1002/chem.201102655 (Original work published 2012)