Reduction of the dose of radiotherapy to the elective neck in head and neck squamous cell carcinoma; a randomized clinical trial. Effect on late toxicity and tumor control.
A multi-center prospective randomized clinical trial has been performed investigating whether a reduction of the dose to the elective nodal sites in head and neck cancer delivered by intensity modulated radiotherapy (IMRT) would result in a reduction of late side effects without compromising tumor control.
Nevens, D., Duprez, F., Daisne, J.-F., Dok, R., Belmans, A., Voordeckers, M., Van den Weyngaert, D., De Neve, W., & Nuyts, S. (2017). Reduction of the dose of radiotherapy to the elective neck in head and neck squamous cell carcinoma; a randomized clinical trial. Effect on late toxicity and tumor control. Radiotherapy & Oncology, 122(2), 171-177. https://doi.org/10.1016/j.radonc.2016.08.009 (Original work published 2017)