Quantitative and qualitative analysis of metabolic response at interim positron emission tomography scan combined with International Prognostic Index is highly predictive of outcome in diffuse large B-cell lymphoma.

Nols, Nathalie;Mounier, Nicolas;Bouazza, Salima;Lhommel, Renaud;Van Den Neste, Eric;et.al.
(2014) Leukemia and Lymphoma — Vol. 55, n° 4, p. 773-780 (2014)

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Abstract
The prognostic value of interim (18)fluorodeoxyglucose positron emission tomography (i-PET) was investigated in 73 patients (median age 60 years) with diffuse large B-cell lymphoma (DLBCL). i-PET was analyzed using the Deauville score (DS) and change in maximum standardized uptake value (ΔSUVmax). Patients with a DS of 1-3 demonstrated a significantly (p < 0.0001) better outcome (median follow-up 2.4 years) than patients with a score of 4 or 5 in terms of event-free survival (EFS) (79% vs. 36%), progression-free survival (PFS) (84% vs. 47%) and overall survival (OS) (91% vs. 51%). EFS (73% vs. 42%), PFS (78% vs. 50%) and OS (88% vs. 56%) were also significantly (p = 0.023) different between patients with ΔSUVmax > 66% or ≤ 66%. Patients (n = 33) combining a favorable age-adjusted International Prognostic Index (IPI) (0 or 1) and a negative i-PET either by DS or ΔSUVmax criteria showed a particularly good outcome (EFS: 85%, PFS: 88%, OS: 94%). Overall, i-PET was highly and independently predictive of any outcome, and its negative predictive value was improved by combination with IPI.
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Nols, N., Mounier, N., Bouazza, S., Lhommel, R., Costantini, S., Vander Borght, T., Vekemans, M.-C., Sonet, A., Bosly, A., Michaux, L., André, M., & Van Den Neste, E. (2014). Quantitative and qualitative analysis of metabolic response at interim positron emission tomography scan combined with International Prognostic Index is highly predictive of outcome in diffuse large B-cell lymphoma. Leukemia and Lymphoma, 55(4), 773-780. https://doi.org/10.3109/10428194.2013.831848 (Original work published 2014)