Inhibition of trypsin by the beta-amyloid protein precursor. A comparative study between transfected cells, human brain and cerebrospinal fluid.

Delvaux, A.;Van der Elst, L.;Octave, Jean-Noël
(1992) FEBS Letters — Vol. 297, n° 1-2, p. 124-126 (1992)

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Abstract
Soluble beta-amyloid protein precursors (beta-APPs) were studied in human brain and cerebrospinal fluid (CSF) after partial purification by ion exchange chromatography. Proteins were analysed in immunoblotting experiments using a monoclonal antibody directed against the N-terminal segment of the beta-APP 770, and by reverse enzymography. In the human brain and CSF, a protein which comigrates with the beta-APP 770 expressed by transfected CHO cells was able to inhibit trypsin.
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Delvaux, A., Van der Elst, L., & Octave, J.-N. (1992). Inhibition of trypsin by the beta-amyloid protein precursor. A comparative study between transfected cells, human brain and cerebrospinal fluid. FEBS Letters, 297(1-2), 124-126. https://doi.org/10.1016/0014-5793(92)80341-D (Original work published 1992)