Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c.

Achouri, Younes;Hegarty, B D;Allanic, D;Bécard, D;Foufelle, F;et.al.
(2005) Biochimie : an international journal of biochemistry and molecular biology — Vol. 87, n° 12, p. 1149-1155 (2005)

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Authors
  • Achouri, YounesUCLouvain
    Author
  • Hegarty, B D
    Author
  • Allanic, D
    Author
  • Bécard, D
    Author
  • Foufelle, FUCLouvain
    Author
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Abstract
In a screen for sterol regulatory element-binding protein (SREBP)-1c target genes in the liver, we identified long chain fatty acyl-CoA synthetase 5 (ACS-5). Hepatic ACS-5 mRNA is poorly expressed during fasting and diabetes and strongly induced by carbohydrate refeeding and insulin treatment. In cultured hepatocytes, insulin and a high glucose concentration induce ACS-5 mRNA. Adenoviral overexpression of a nuclear form of SREBP-1c in liver of diabetic mice or in cultured hepatocytes mimics the effect of insulin to induce ACS-5. By contrast, a dominant negative form of SREBP-1c abolishes the effect of insulin on ACS-5 expression. The dietary and SREBP-1c-mediated insulin regulation of ACS-5 expression indicate that ACS-5 is involved in the anabolic fate of fatty acids.
Affiliations
  • Université Paris 6

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Achouri, Y., Hegarty, B. D., Allanic, D., Bécard, D., Hainault, I., Ferré, P., & Foufelle, F. (2005). Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c. Biochimie : an international journal of biochemistry and molecular biology, 87(12), 1149-1155. https://doi.org/10.1016/j.biochi.2005.04.015 (Original work published 2005)