Increased CD8CD28 circulating T cells and high blood interferon score characterize the systemic inflammation of amyopathic dermatomyositis.
(2019) Journal of the American academy of dermatology — Vol. 85, n° 3, p. 755-758 (2019)
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- (en) Amyopathic dermatomyositis (ADM) is a subtype of DM defined by the presence of cutaneous signs of DM with no evidence of muscle weakness or abnormal muscle enzymes for ≥ 6 months.1 Classical DM (CDM) is characterized by modification of circulating lymphocytes 4, type I interferon (IFN) signature 2, elevation of serum pro-inflammatory cytokines 3. Pathophysiology of ADM is less studied. We analysed circulating T cells by flowcytometry (using specific monoclonal antibodies), peripheral blood mononuclear cells type I IFN signature by PCR and serum cytokine levels by ELISA in a series of 17 ADM and 15 CDM patients. [...]
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Cassius, C., Branchtein, M., Battistella, M., Amode, R., Lepelletier, C., Jachiet, M., de Masson, A., Frumholtz, L., Chasset, F., Monfort, J.-B., Bachmeyer, C., Bengoufa, D., Cordoliani, F., Bagot, M., Bensussan, A., Le Buanec, H., & Bouaziz, J.-D. (2019). Increased CD8CD28 circulating T cells and high blood interferon score characterize the systemic inflammation of amyopathic dermatomyositis. Journal of the American academy of dermatology, 85(3), 755-758. https://doi.org/10.1016/j.jaad.2019.11.036 (Original work published 2019)