Liver transplantation in children with fulminant hepatic failure: The UCL experience.
(2009) Pediatric Transplantation — Vol. 13, n° 4, p. 414-420 (2009)
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- Authors
Sokal, Etienne 
- Abstract
- The outcome of pediatric LT for FHF was shown to be poor in our center. To better understand such results, recipient and transplant parameters with a putative impact on post-transplant outcome were analyzed in LT for FHF. Between March 1984 and June 2002, 33 children with FHF received a primary liver allograft. The overall results in this series were studied with respect to pre-operative demographic and metabolic variables, peri-operative events, and outcome. Five-yr patient and graft survivals were 71% and 66%, respectively, with a retransplantation rate at 18%. Incidences of perioperative hemorrhage, of HAT and PVT were 14%, 8%, and 4%, respectively. Five-yr acute rejection-free survival rate was 55%. These data confirm the worse outcome following LT for FHF when compared with LT in elective, non-malignant indications such as BA; results in FHF could not be related to surgical or immunological complications in the post-transplant period and it is hypothesized that the MOF associated with FHF contributes to early post-transplant mortality which would justify special management, including aggressive renal and hepatic support.
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Citations
Mahadeb, P., Gras, J., Sokal, E., Otte, J.-B., Lerut, J., Detaille, T., Clément de Cléty, S., & Reding, R. (2009). Liver transplantation in children with fulminant hepatic failure: The UCL experience. Pediatric Transplantation, 13(4), 414-420. https://doi.org/10.1111/j.1399-3046.2008.01008.x (Original work published 2009)