Predisposition to familial osteoarthrosis linked to type II collagen gene.

Palotie, A;Väisänen, P;Ott, J;Ryhänen, L;Peltonen, L;et.al.
(1989) The Lancet — Vol. 1, n° 8644, p. 924-927 (1989)

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Authors
  • Palotie, A
    Author
  • Väisänen, P
    Author
  • Ott, J
    Author
  • Ryhänen, L
    Author
  • Vikkula, MiikkaUCLouvain
    Author
  • Peltonen, L
    Author
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Abstract
The genetic background of two families, in whom a predisposition to primary osteoarthrosis is inherited as a dominant trait, was investigated. Use of restriction fragment length polymorphisms within and around the type II collagen gene on chromosome 12 revealed a linkage between this cartilage-specific gene and primary osteoarthrosis.
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Palotie, A., Väisänen, P., Ott, J., Ryhänen, L., Elima, K., Vikkula, M., Cheah, K., Vuorio, E., & Peltonen, L. (1989). Predisposition to familial osteoarthrosis linked to type II collagen gene. The Lancet, 1(8644), 924-927. https://hdl.handle.net/2078.5/160387 (Original work published 1989)