Novel analogues of the anti HIV-1 agent TSAO-T modified at the 3'-spiro moiety.

Alvarez, R;Jimeno, ML;De Clercq, Etienne;Balzarini, Jan;Camarasa, MJ
(1997) XII International Round Table on Nucleosides, Nucleotides and their Biological Applications - Making Drugs Out of Nucleosides and Oligonucleotides — Location: LA JOLLA(Ca) (15.September.1996)

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Authors
  • Alvarez, R
    Author
  • Jimeno, ML
    Author
  • De Clercq, EtienneUCLouvain
    Author
  • Balzarini, JanKUL
    Author
  • Camarasa, MJ
    Author
Abstract
Novel TSAO-T analogues, in which the 3'-spiroaminooxatioledioxide moiety has been replaced by other 3'-spiro moieties bearing a NH group at the same position as the 4 ''-NH2 of TSAO-T have been prepared and evaluated for their inhibitory effect on HIV replication in cell culture. In contrast to the prototype compound TSAO-T, the novel TSAO derivatives were inactive at subtoxic concentrations.
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Alvarez, R., Jimeno, M., De Clercq, E., Balzarini, J., & Camarasa, M. (1997). Novel analogues of the anti HIV-1 agent TSAO-T modified at the 3′-spiro moiety. Nucleosides and Nucleotides, 16(7-9), 1033-1036. https://doi.org/10.1080/07328319708006126 (Original work published 1997)