Pulmonary tumor thrombotic microangiopathy in a patient with a metastatic urothelial carcinoma.

Pinto Pereira, Joao;Lelotte, Julie;Ghaye, Benoît;Laterre, Pierre-François;Hantson, Philippe
(2021) Urology case reports — Vol. 38, p. 101668 [1-32] (2021)

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A 78-year-old woman was admitted for acute dyspnoea. One year before, she had been treated with cisplatin and gemcitabine for a high grade urothelial carcinoma. Immunotherapy was discussed 9 months later due the progression of bone metastases but could not be administered before this episode of respiratory distress. There was a major discrepancy between the findings of a limited pulmonary embolism at thoracic tomodensitometry and the severity of a recently developed pulmonary hypertension at echocardiography. The patient presented cardiac arrest on day 6 and post-mortem findings were consistent with diffuse pulmonary tumor thrombotic microangiopathy, a rare complication of urothelial carcinoma.
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Pinto Pereira, J., Lelotte, J., Ghaye, B., Laterre, P.-F., & Hantson, P. (2021). Pulmonary tumor thrombotic microangiopathy in a patient with a metastatic urothelial carcinoma. Urology case reports, 38, 101668 [1-32]. https://doi.org/10.1016/j.eucr.2021.101668 (Original work published 2021)