(en) Hepatic involvement by sickle cell disease (SCD) can result in a variety of symptoms ranging from mild to life-threatening. Acute intrahepatic cholestasis is a rare but often fatal condition, with multi-organ failure as a terminal event. The following observation is suggesting that extreme hyperbilirubinemia may be associated with energetic failure. [...]
Masy, V., Sokal, E., Ranguelov, N., Brichard, B., Laterre, P.-F., & Hantson, P. (2019). Fatal type B lactic acidosis in a patient with end-stage liver disease related to homozygous sickle cell disease. Annals of hematology, 98(11), 2627-2628. https://doi.org/10.1007/s00277-019-03822-8 (Original work published 2019)