Small dense-cored vesicles are depleted of the classical synaptic vesicle membrane proteins synaptobrevin, synaptotagmin and Rab3
(2001) Neuroscience Research Communications — Vol. 28, n° 3, p. 173-179 (2001)
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- To verify the association of vesicular docking/fusion proteins to small dense-cored vesicles, we further purified a small dense-cored vesicle population from rat vas deferens and searched for three components of the vesicular docking/fusion machinery known to act on target receptors at the plasma membrane: synaptobrevin (p18), synaptotagmin (p65) and the small GTPase Rab3. Further purification of small dense-cored vesicles actually resulted in a depletion of these proteins, arguing against a direct participation of small dense-cored vesicles in the exocytotic process. This finding points to a functional difference between small dense-cored vesicles and either large dense-cored or small clear synaptic vesicles.
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Strecker, S., Partoens, P., Slembrouck, D., Wang, JM., Courtoy, P., Nouwen, E., & De Potter, W. (2001). Small dense-cored vesicles are depleted of the classical synaptic vesicle membrane proteins synaptobrevin, synaptotagmin and Rab3. Neuroscience Research Communications, 28(3), 173-179. https://doi.org/10.1002/nrc.1018 (Original work published 2001)