Prognostic Factors for Pulmonary Embolism The PREP Study, A Prospective Multicenter Cohort Study
(2010) American Journal of Respiratory and Critical Care Medicine — Vol. 181, n° 2, p. 168-173 (2010)
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- Rationale: The short-term prognosis of pulmonary embolism (PE) depends on hemodynamic status and underlying disease. The prognostic value of right ventricular dysfunction and injury is less well established. Objectives: To evaluate prognostic factors of PE in a multicenter prospective cohort study. Methods: Echocardiography, brain natriuretic peptide (BNP), N-terminal-proBNP and cardiac troponin I measurements were done on admission of 570 consecutive patients with an acute PE. A predictive model was based on independent predictors of 30-day adverse events defined as death, secondary cardiogenic shock, or recurrent venous thromboembolism. Measurements and Main Results: At 30 days, 42 patients (7.4%; 95% confidence interval [CI], 5.5-9.8%) had adverse events. On multivariate analysis, altered mental state (odds ratio [OR] 6.8; 95% confidence interval [CI], 2.0-23.3), shock on admission (OR 2.8; 95% Cl, 1.1-7.5), cancer (OR 2.9; 95% Cl, 1.2-6.9), BNP (OR 1.3 for an increase of 250 ng/L; 95% Cl, 1.1-1.6) and right to left ventricle diameter ratio (OR 1.2 for an increase of 0.1; 95% Cl, 1.1-1.4) were associated with 30-days of adverse events. The predictive performance of the model was good (area under receiver operating characteristics curve 0.84 [95% Cl, 0.78-0.90]), making it possible to develop a bedside prognostic score. Conclusions: BNP and echocardiography may be useful determinants of the short-term outcome for patients with PE, together with clinical findings. Patients with PE can be stratified according to the initial risk of adverse outcome, using a simple score based on clinical, echocardiographic, and biochemical variables.
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Sanchez, O., Verschuren, F., Trinquart, L., Caille, V., Couturaud, F., Pacouret, G., Meneveau, N., Roy, P.-M., Parent, F., Righini, M., Perrier, A., Lorut, C., Tardy, B., Benoit, M.-O., Chatellier, G., & Meyer, G. (2010). Prognostic Factors for Pulmonary Embolism The PREP Study, A Prospective Multicenter Cohort Study. American Journal of Respiratory and Critical Care Medicine, 181(2), 168-173. https://doi.org/10.1164/rccm.200906-0970OC (Original work published 2010)