Freeze-dried irradiated bone brittleness improves compactness in an impaction bone grafting model.
(2004) Acta Orthopaedica Scandinavica — Vol. 75, n° 3, p. 309-314 (2004)
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- BACKGROUND: Defatted bone chips with or without freeze-drying and irradiation have mechanical advantages as compared to fresh-frozen controls in in vitro models of impaction. These improved results have been ascribed to replacement of viscous bone marrow by saline and embrittlement of the freeze-dried bone by irradiation. MATERIAL AND METHODS: To determine which of these hypotheses is correct, we compared the development of stiffness and compactness of morselized bone graft that had been: 1) fat-reduced with saline, and 2) fresh-frozen, solvent-detergent defatted, 3) freeze-dried irradiated and 4) not irradiated. We used 12 osteoarthrotic femoral heads to prepare these four batches of morselized bone, and impacted 18 samples from each batch in a cylinder. The frozen bone grafts were tested after thawing at room temperature for 2 hours and the freeze-dried grafts were tested after 30 minutes of rehydration. We monitored the development of compactness and stiffness of the material during impaction. RESULTS: The stiffness of the freeze-dried irradiated bone was greater than that of the other three series after 10, 50 and 150 impactions. The freeze-dried bone chips that were not irradiated and the chips defatted with saline alone were less stiff than the fresh-frozen control after 150 impactions. INTERPRETATION: The brittleness of freeze-dried irradiated bone, caused by loss of the capacity to absorb energy in a plastic way, increases the compactness and stiffness of the morselized grafts. Washing bone with saline alone or treating bone with solvent-detergent but no irradiation had no similar mechanical advantage and the bone did not impact better than fresh-frozen undefatted bone in our model.
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Cornu, O., Libouton, X., Naets, B., Godts, B., Van Tomme, J., Delloye, C., & Banse, X. (2004). Freeze-dried irradiated bone brittleness improves compactness in an impaction bone grafting model. Acta Orthopaedica Scandinavica, 75(3), 309-314. https://doi.org/10.1080/00016470410001240 (Original work published 2004)