Modern thrombolytic strategies have substantially attenuated the absolute mortality benefit of PPCI over thrombolysis, particularly in patients not at high risk. Our study findings suggest that target door-to-balloon time should be less than 60 minutes to maintain the lowest mortality rates.
Claeys, M. J., de Meester, A., Convens, C., Dubois, P., Boland, J., De Raedt, H., Vranckx, P., Coussement, P., Gevaert, S., Sinnaeve, P., Evrard, P., Beauloye, C., Renard, M., & Vrints, C. (2011). Contemporary mortality differences between primary percutaneous coronary intervention and thrombolysis in ST-segment elevation myocardial infarction. Archives of Internal Medicine, 171(6), 544-549. https://doi.org/10.1001/archinternmed.2011.57 (Original work published 2011)