Cross-biome comparison of microbial association networks
(2015) Frontiers in Microbiology — Vol. 6, n° 1, p. 1200 (2015)
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- Clinicalandenvironmentalmeta-omicsstudiesareaccumulatinganever-growingamountofmicrobialabundancedataoverawiderangeofecosystems.Withasufficientlylargesamplenumber,thesemicrobialcommunitiescanbeexploredbyconstructingandanalyzingco-occurrencenetworks,whichdetecttaxonassociationsfromabundancedataandcangiveinsightsintocommunitystructure.Here,weinvestigatehowco-occurrencenetworksdifferacrossbiomesandwhichotherfactorsinfluencetheirproperties.Forthis,weinferredmicrobialassociationnetworksfrom20different16SrDNAsequencingdatasetsandobservedthatsoilmicrobialnetworksharborproportionallyfewerpositiveassociationsandarelessdenselyinterconnectedthanhost-associatednetworks.Afterexcludingsamplenumber,sequencingdepthandbeta-diversityaspossibledrivers,wefoundanegativecorrelationbetweencommunityevennessandpositiveedgepercentage.Thiscorrelationlikelyresultsfromaskeweddistributionofnegativeinteractions,whichtakeplacepreferentiallybetweenlessprevalenttaxa.Overall,ourresultssuggestanunder-appreciatedroleofevennessinshapingmicrobialassociationnetworks.
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Faust, K., Lima Mendez, G., Lerat, J.-S., Sathirapongsasuti, J. F., Knight, R., Huttenhower, C., Lenaerts, T., & Raes, J. (2015). Cross-biome comparison of microbial association networks. Frontiers in Microbiology, 6(1), 1200. https://doi.org/10.3389/fmicb.2015.01200 (Original work published 2015)