Human Interleukin-10 Induces Naive Surface-immunoglobulin D+ (sigd(+)) B-cells To Secrete Igg1 and Igg3
(1994) The Journal of Experimental Medicine — Vol. 179, n° 2, p. 757-762 (1994)
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- During antigen-induced immune responses, human B cells switch isotype from immunoglobulin M (IgM)-IgD to IgG1-4, IgA1-2, or IgE. In the human, no cytokines have yet been demonstrated to act as switch factors for IgG1, IgG2, and IgG3. In this paper, we report that in response to interleukin 10 (IL-10), anti-CD40 activated tonsillar surface IgD(+) (sIgD(+))B cells are induced to secrete large amounts of IgM, IgG1, and IgG3 but neither IgG2 nor IgG4. Cord blood purified B cells and lymphocytes from Hyper-IgM patients also produced IgG1 and IgG3 after culture with anti-CD40 and IL-10. In contrast, sIgD(-) isotype-committed B cells produce IgG1, IgG2, and IgG3 when activated through CD40 in the presence of IL-10. Thus, in addition to its growth-promoting and differentiating activities on human B cells, IL-10 may represent a switch factor for IgG1 and IgG3.
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Brière, F., Servetdelprat, C., Bridon, J., Saintremy, JM., & Banchereau, J. (1994). Human Interleukin-10 Induces Naive Surface-immunoglobulin D+ (sigd(+)) B-cells To Secrete Igg1 and Igg3. The Journal of Experimental Medicine, 179(2), 757-762. https://doi.org/10.1084/jem.179.2.757 (Original work published 1994)