Studies into the synthesis of derivatives of 4-amino-2,3-dihydroisothiazole 1,1-dioxides and 4-amino-1,2-oxathiole 2,2-dioxides: The search for linked pi-system containing analogues as potential inhibitors of HIV-1 reverse transcriptase

Ingate, ST;Marco, JL;Witvrouw, M;Pannecouque, C;De Clercq, Etienne
(1997) Tetrahedron — Vol. 53, n° 52, p. 17795-17814 (1997)

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Authors
  • Ingate, ST
    Author
  • Marco, JL
    Author
  • Witvrouw, M
    Author
  • Pannecouque, C
    Author
  • De Clercq, EtienneUCLouvain
    Author
Abstract
The synthesis, and anti HIV-1 activity, of new derivatives of 4-amino-1,2-oxathiole 2,2-dioxide (3, 5, 6 and 9) and 4-amino-2,3-dihydroisothiazole 1,l-dioxide (14). a new heterocyclic ring system, is described. (C) 1997 Elsevier Science Ltd.
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Ingate, S., Marco, J., Witvrouw, M., Pannecouque, C., & De Clercq, E. (1997). Studies into the synthesis of derivatives of 4-amino-2,3-dihydroisothiazole 1,1-dioxides and 4-amino-1,2-oxathiole 2,2-dioxides: The search for linked pi-system containing analogues as potential inhibitors of HIV-1 reverse transcriptase. Tetrahedron, 53(52), 17795-17814. https://doi.org/10.1016/S0040-4020(97)10244-7 (Original work published 1997)