Impact of the Age-Adjusted D-Dimer Cutoff to Exclude Pulmonary Embolism : A Multinational Prospective Real-Life Study (the RELAX-PE Study)

Robert-Ebadi, Helia;Robin, Philippe;Hugli, Olivier;Verschuren, Franck;Righini, Marc;et.al.
(2021) Circulation — Vol. 143, n° 18, p. 1828-1830 (2021)

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  • Robert-Ebadi, Heliaorcid-logo
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  • Robin, Philippe
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  • Hugli, Olivier
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  • Verschuren, FranckUCLouvain
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  • Righini, Marc
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Abstract
(en) Diagnosis of pulmonary embolism (PE) relies on the sequential use of pretest probability (PTP), plasma D-dimer, and computed tomography pulmonary angiography. D-dimer <500 µg/L safely excludes PE in association with a low or intermediate (nonhigh) PTP in approximately one-third of outpatients. To increase the clinical usefulness of D-dimer, a cutoff adjusted to patient’s age was explored. [...]
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Robert-Ebadi, H., Robin, P., Hugli, O., Verschuren, F., Trinh-Duc, A., Roy, P.-M., Schmidt, J., Fumeaux, T., Meyer, G., Hayoz, D., Carron, P.-N., Salaun, P.-Y., Sarasin, F., Rutschmann, O., Le Gal, G., & Righini, M. (2021). Impact of the Age-Adjusted D-Dimer Cutoff to Exclude Pulmonary Embolism : A Multinational Prospective Real-Life Study (the RELAX-PE Study). Circulation, 143(18), 1828-1830. https://doi.org/10.1161/circulationaha.120.052780 (Original work published 2021)