(2-methylthio-3-pyridinecarboxylato)-diethyltin and -di-n-butyltin Compounds - Synthesis, Spectroscopic Characterization and Invitro Antitumor-activity - X-ray Crystal-structure of Bis[diethyl(2-methylthio-3-pyridinecarboxylato)tin] Oxide and of Diethyltin Bis(2-methylthio-3-pyridinecarboxylate)

Gielen, M.;Elkhloufi, A.;Biesemans, M.;Willem, R.;Meunierpiret, J.
(1992) Polyhedron — Vol. 11, n° 15, p. 1861-1868 (1992)

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Authors
  • Gielen, M.
    Author
  • Elkhloufi, A.
    Author
  • Biesemans, M.
    Author
  • Willem, R.
    Author
  • Meunierpiret, J.
    Author
Abstract
The X-ray crystal structures of [diethyl(2-methylthio-3-pyridinecarboxylato)tin] oxide (1a) and diethyltin bis(2-methylthio-3-pyridinecarboxylate) (1b) were determined. Compound 1a is a centrosymmetric dimer with two distinct types of carboxylate moieties and tin atoms with trigonal bipyramidal geometries. Compound 1b is monomeric with a six-coordinate tin atom and two equivalent carboxylate groups chelating the tin atom. Compounds 2a and 2b, the di-n-butyl analogues of 1a and 1b, have also been synthesized and characterized spectroscopically. The in vitro activity of compounds 2b and 2a against the human tumour cell line WiDr, a colon carcinoma, is better than that of cis-platin and doxorubicin. They are much less active than doxorubicin against MCF-7, a mammary tumour cell line. Compound 1b is inactive.
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Gielen, M., Elkhloufi, A., Biesemans, M., Willem, R., & Meunierpiret, J. (1992). (2-methylthio-3-pyridinecarboxylato)-diethyltin and -di-n-butyltin Compounds - Synthesis, Spectroscopic Characterization and Invitro Antitumor-activity - X-ray Crystal-structure of Bis[diethyl(2-methylthio-3-pyridinecarboxylato)tin] Oxide and of Diethyltin Bis(2-methylthio-3-pyridinecarboxylate). Polyhedron, 11(15), 1861-1868. https://doi.org/10.1016/S0277-5387(00)83733-X (Original work published 1992)