Synthesis of chiral beta-aminoalcohol palladium complexes exhibiting cytotoxic properties
(2010) Dalton Transactions (Online) : the international journal for inorganic, organometallic and bioinorganic chemistry — Vol. 39, n° 38, p. 8982-8993 (2010)
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- Abstract
- Original palladium complexes involving (-)-ephedrine, (-)-norephedrine, L-prolinol, L-valinol and L-isoleucinol have been rapidly prepared in neutral or basic medium and simply purified. They have been fully characterized by classical analytical methods and four of them were characterized by X-Ray analysis. In parallel with the experimental work, HF-DFT(B3LYP/PCM) computations were performed to obtain additional structural information. Their antiproliferative properties have been evaluated and some complexes showed small activities especially towards HT29 human cancer cells.
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Accadbled, F., Tinant, B., Henon, E., Carrez, D., Croisy, A., & Bouquillon, S. (2010). Synthesis of chiral beta-aminoalcohol palladium complexes exhibiting cytotoxic properties. Dalton Transactions (Online) : the international journal for inorganic, organometallic and bioinorganic chemistry, 39(38), 8982-8993. https://doi.org/10.1039/c0dt00328j (Original work published 2010)