Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta.
(1987) Skeletal radiology — Vol. 16, n° 5, p. 360-363 (1987)
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- Abstract
- A 12-year-old female suffering from osteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration of therapy was 1 year. Radiological and clinical improvement was striking. Furthermore, X-rays of the bones showed large, parallel radio-opaque striae, corresponding exactly to the periods of therapy. These were present in all metaphyses.
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Devogelaer, J.-P., Malghem, J., Maldague, B., & Nagant de Deuxchaisnes, C. (1987). Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta. Skeletal radiology, 16(5), 360-363. https://doi.org/10.1007/BF00350961 (Original work published 1987)