Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022.

de Kleine, Ruben H;Lexmond, Willem S;Buescher, Gustav;Sturm, Ekkehard;Stephenne, Xavier;et.al.
(2022) Eurosurveillance (Print) — Vol. 27, n° 19, p. 2200369 [1-7] (2022)

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Authors
  • de Kleine, Ruben H
    Author
  • Lexmond, Willem S
    Author
  • Buescher, Gustav
    Author
  • Sturm, Ekkehard
    Author
  • Stephenne, XavierUCLouvain
    Collaborator
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Abstract
To detect potential concern about severe acute hepatitis in children, we conducted a survey among 50 ERN RARE-LIVER centres. By 26 April 2022, 34 centres, including 25 transplant centres, reported an estimated median of 3-5, 0-2 and 3-5 cases in 2021, 2020 and 2019 and a mean of 2 (range: 0-8) cases between January and April 2022 (mean in 10 large liver transplant centres: 3). Twelve centres reported suspicion of an increase, but no rise.
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de Kleine, R. H., Lexmond, W. S., Buescher, G., Sturm, E., Kelly, D., Lohse, A. W., Lenz, D., & Hørby Jørgensen, M. (2022). Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022. Eurosurveillance (Print), 27(19), 2200369 [1-7]. https://doi.org/10.2807/1560-7917.ES.2022.27.19.2200369 (Original work published 2022)