A biomimetic synthesis of coelenterazine analogs

Devillers, Ingrid;Arrault, Axelle;Olive, Gilles;Marchand-Brynaert, Jacqueline
(2002) Tetrahedron Letters — Vol. 43, n° 17, p. 3161-3164 (2002)

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Authors
  • Devillers, IngridUCLouvain
    Author
  • Arrault, AxelleUCLouvain
    Author
  • Olive, GillesUCLouvain
    Author
  • Marchand-Brynaert, JacquelineUCLouvain
    Author
Abstract
N-(Trifluoroacetyl)dehydrodipeptides 2-3 were coupled to aminomethylene dimethylacetal derivatives 4 5. The resulting pseudo-tripeptides 6 were stepwise deprotected (carbonyl function (7) then amine function) and in situ cyclized into imidazolopyrazines 1. (C) 2002 Elsevier Science Ltd. All rights reserved.
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Devillers, I., Arrault, A., Olive, G., & Marchand-Brynaert, J. (2002). A biomimetic synthesis of coelenterazine analogs. Tetrahedron Letters, 43(17), 3161-3164. https://doi.org/10.1016/S0040-4039(02)00462-8 (Original work published 2002)