HLA-G expression and regulation duringPseudomonas aeruginosainfection in cystic fibrosis patients
(2016) Future Microbiology — Vol. 11, n° 3, p. 363-373 (2016)
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- Abstract
- BACKGROUND: Deregulated immune response fails to control biofilm-forming bacteria, as Pseudomonas aeruginosa, in the lungs of cystic fibrosis (CF) patients. HLA-G is an immune-modulatory molecule involved in respiratory diseases and infections. MATERIALS & METHODS: HLA-G mRNA and protein were analyzed in plasma and exhaled breath condensate from CF patients undergoing intravenous antibiotic treatment, CF cell line and murine model. RESULTS: Therapy normalizes HLA-G plasmatic in CF patients suggesting a systemic anti-inflammatory role while in CF airway system, higher expression of HLA-G is associated with P. aeruginosa infection. CF cell line and murine model expressed higher HLA-G molecules in the presence of P. aeruginosa. CONCLUSION: Plasmatic and lung HLA-G expression suggest a role in reducing systemic inflammation and supporting P. aeruginosa infection
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Rizzo, R., Bergamini, G., Bortolotti, D., Leal, T., D’Orazio, C., Pintani, E., Melchiorri, L., Zavatti, E., Assael, B. M., Sorio, C., & Melotti, P. (2016). HLA-G expression and regulation duringPseudomonas aeruginosainfection in cystic fibrosis patients. Future Microbiology, 11(3), 363-373. https://doi.org/10.2217/fmb.15.143 (Original work published 2016)