What Does the Future Hold for Photo-Oxidizing RuII Complexes with Polyazaaromatic Ligands in Medicinal Chemistry?
(2012) Current Topics in Medicinal Chemistry — Vol. 12, p. 185-196 (2012)
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- Authors
Marcélis, Lionel 
- Abstract
- Since the discovery of cisplatin, the search for diagnostic or therapeutic agents based on other metals, has expanded intensively owing to the numerous possibilities offered by coordination chemistry. This mini-review focuses on recent advances in the search for RuII polyazaaromatic complexes of potential interest as molecular tools applied to cellular diagnostics or as specific cellular photo-reagents for future biomedical applications. The interaction of RuII polyazaaromatic complexes with living cells is reported, as well as the photo-reaction mechanisms of photo-oxidizing RuII complexes with nucleic acids. The novel strategies currently developed to improve their reactivity and specificity towards DNA, more particularly in the gene-silencing framework, are also discussed.
- Affiliations
ULB
Citations
Ghesquiere, J., Le Gac, S., Marcélis, L., Moucheron, C., & Kirsch - De Mesmaeker, A. (2012). What Does the Future Hold for Photo-Oxidizing RuII Complexes with Polyazaaromatic Ligands in Medicinal Chemistry? Current Topics in Medicinal Chemistry, 12, 185-196. https://doi.org/10.2174/156802612799079008 (Original work published 2012)