Versatile CuI/Pd0 dual catalysis for the synthesis of quaternary α-allylated carbonyl compounds: Development, mechanistic investigations and scope

Nahra, Fady;Mace, Yohan;Boreux, Arnaud;Billard, François;Riant, Olivier
(2014) Chemistry: A European Journal — Vol. 20, n° 35, p. 10970-10981 (2014)

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Abstract
We report herein a versatile cooperative dual catalysis reaction based on a CuI/Pd0 system. Mechanistic investigation shows that every component plays a crucial role in determining the reaction outcome. The reaction is successfully extended to various substrates; such as α,β-unsaturated ketones, malonates and coumarins. The strategy tolerates different substitution patterns and affords good yields for each family of substrates. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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Nahra, F., Mace, Y., Boreux, A., Billard, F., & Riant, O. (2014). Versatile CuI/Pd0 dual catalysis for the synthesis of quaternary α-allylated carbonyl compounds: Development, mechanistic investigations and scope. Chemistry: A European Journal, 20(35), 10970-10981. https://doi.org/10.1002/chem.201404015 (Original work published 2014)