Cancers of the urinary system
(2014) Translation and Its Regulation in Cancer Biology and Medicine — ISBN: [978-94-017-9077-2], p. 676-680, published
Files
978-94-017-9078-9_34.pdf
Restricted Access - Adobe PDF
- 1.01 MB
Details
- Authors
- Abstract
- The role of translation and its regulation in cancers of the urinary system is poorly studied and understood, and is limited to investigations of the activity of eIF4E and its binding proteins (4E-BPs) in bladder cancer and, to a lesser extent, RCCs. The lack of studies on this topic is surprising given the established role of the mTOR signaling pathway, which converges on the translation machinery, in the pathobiology and therapeutic targeting in RCC. Nevertheless, the available body of evidence suggests involvement of eIF4E overexpression and activation via the mTOR/4E-BPs module in the biology of cancers of the urinary system. This chapter discusses the current state of our knowledge on alterations of the translation machinery in these malignancies
- Affiliations
Citations
Parsyan, A., Seront, E., & Machiels, J.-P. (2014). Cancers of the urinary system. In Armen Parsyan (ed.) (ed.), Translation and Its Regulation in Cancer Biology and Medicine (p. p. 676-680). Springer. https://doi.org/10.1007/978-94-017-9078-9_34