Ternary and quaternary phase diagrams: Key tools for chiral resolution through solution cocrystallization

Springuel, Géraldine;Collard, Laurent;Leyssens, Tom
(2013) CrystEngComm — Vol. 15, n° 39, p. 7951-7958 (2013)

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The goal of this contribution is to guide the reader through the construction and the understanding of quaternary phase diagrams in the pursuit of optimal conditions for a chiral resolution through cocrystallization in solution. The overall description will be illustrated by experimental results on a system involving RS-2-(2-oxopyrrolidin-1-yl) butanamide as chiral API to be separated, and S-mandelic acid as chiral coformer. © 2013 The Royal Society of Chemistry.
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Springuel, G., Collard, L., & Leyssens, T. (2013). Ternary and quaternary phase diagrams: Key tools for chiral resolution through solution cocrystallization. CrystEngComm, 15(39), 7951-7958. https://doi.org/10.1039/c3ce41141a (Original work published 2013)