Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study

Hegen, Harald; Berek, Klaus; Cavalla, Paola; Christiansen, Mikael; Emeršič, Andreja; Di Filippo, Massimiliano; Gaetani, Lorenzo; Hassler, Michaela; Leurs, Cyra; Milosavljevic, Dejan; Van Pesch, Vincent; Petersen, Thor; Presslauer, Stefan; Rosenstein, Igal; Rot, Uroš; Schnabl, Christine; Teunissen, Charlotte; Vecchio, Domizia; Vercellino, Marco; Deisenhammer, Florian

doi:10.3389/fimmu.2023.1327947

Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study

Hegen, Harald

;

Berek, Klaus

;

Cavalla, Paola

;

Christiansen, Mikael

;

Deisenhammer, Florian

;et.al.

(2023) Frontiers in Immunology — Vol. 14, p. 1327947 [1-6] (2023)

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Authors

Hegen, Harald
Author
Berek, Klaus
Author
Cavalla, Paola
Author
Christiansen, Mikael
Author
Van Pesch, VincentUCLouvain
Author
Deisenhammer, Florian
Author

Abstract

(en) BACKGROUND: Kappa free light chains (κ-FLC) in the cerebrospinal fluid (CSF) are an emerging biomarker in multiple sclerosis (MS). OBJECTIVE: To investigate whether κ-FLC index has similar diagnostic value in patients with primary progressive multiple sclerosis (PPMS) compared to oligoclonal bands (OCB). METHODS: Patients with PPMS were recruited through 11 MS centres across 7 countries. κ-FLC were measured by immunonephelometry/-turbidimetry. OCB were determined by isoelectric focusing and immunofixation. RESULTS: A total of 174 patients (mean age of 52±11 years, 51% males) were included. κ-FLC index using a cut-off of 6.1 was positive in 161 (93%) and OCB in 153 (88%) patients. CONCLUSION: κ-FLC index shows similar diagnostic sensitivity than OCB in PPMS.

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Hegen, H., Berek, K., Cavalla, P., Christiansen, M., Emeršič, A., Di Filippo, M., Gaetani, L., Hassler, M., Leurs, C., Milosavljevic, D., Van Pesch, V., Petersen, T., Presslauer, S., Rosenstein, I., Rot, U., Schnabl, C., Teunissen, C., Vecchio, D., Vercellino, M., & Deisenhammer, F. (2023). Diagnostic value of kappa free light chain index in patients with primary progressive multiple sclerosis – a multicentre study. Frontiers in Immunology, 14, 1327947 [1-6]. https://doi.org/10.3389/fimmu.2023.1327947 (Original work published 2023)